DC maturation

DC-SIGN modulates DC maturation and function in rat renal tubulointerstitial lesions.

The role of DC-SIGN in tubulointerstitial lesions (TILs) and the effect of anti-P-selectin lectin-EGF domain monoclonal antibody (PsL-EGFmAb) were investigated in rat nephrotoxic nephritis (NTN). On Day 4, immature DC-SIGN+DCs infiltrated into renal tubulointerstitium and matured by Day 14, showing increased migratory capacity and ability to induce T cell proliferation. The distribution of DC-S...

A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment.

We have identified a novel lysosome-associated membrane glycoprotein localized on chromosome 3q26.3-q27, DC-LAMP, which is homologous to CD68. DC-LAMP mRNA is present only in lymphoid organs and DC. A specific MAb detects the protein exclusively in interdigitating dendritic cells. Expression of DC-LAMP increases progressively during in vitro DC differentiation, but sharply upon activation with ...

AC-DC & DC-DC Converters for DC Motor Drives

This paper deals with a comprehensive survey on the topic of AC/DC & DC/DC converters for DC Motor Drives. A substantial number of different AC/DC and DC/DC topologies appropriate for DC motor drives are presented. This critical literature review brings out merits, demerits, and limitations besides giving the basic operating principles of various topologies. Keywords—controlled-rectifiers, chop...

Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing

The activation, or maturation, of dendritic cells (DCs) is crucial for the initiation of adaptive T-cell mediated immune responses. Research on the molecular mechanisms implicated in DC maturation has focused primarily on inducible gene-expression events promoting the acquisition of new functions, such as cytokine production and enhanced T-cell-stimulatory capacity. In contrast, mechanisms that...

Interleukin-21 inhibits dendritic cell activation and maturation Short title: IL-21 inhibits DC activation